Potassium tert-butoxide Cas 865-47-4

Strong bases for organic synthesis: Used in enolate preparation, Hofmann elimination, and deprotonation reactions; carbon-carbon bond formation; and as catalysts for Wittig and condensation reactions.
Synthesis of pharmaceutical intermediates: Commonly used deprotonating agents for synthesizing heterocyclic drugs, steroid drugs, and chiral active pharmaceutical ingredients (APIs); serves as a substitute for strong bases such as NaH and sodium amide.
Catalysts for olefin isomerization and deprotonation: Facilitates α-alkylation of esters, ketones, and nitriles; promotes the formation of carbanion intermediates.
Polymer synthesis: Initiators for anionic polymerization; catalysts for the modification of silicones and polyolefins.
Fine chemicals and fragrance synthesis: Condensation and rearrangement reactions involving terpenes and fragrance intermediates.